We are very proud to present a selection of world-leading scientists within non-coding RNA research. Each speaker has been hand-picked to cover an important part of this fast-growing and exciting research field. The meeting is open to all researchers and aim to address the the role of non-coding RNAs in metabolism.
Krook Anna group - Integrative Physiology
Karolinska Institutet, Stockholm, Sweden
Research in laboratory is focused on understanding the regulation of skeletal muscle insulin sensitivity- with a particular interest in the role of miRNA
Biotech Research & Innovation Centre
University of Copenhagen, Denmark
A key current interest in the laboratory is to try to decipher how the ribosome is regulated, and how this regulation in turn impacts on the interpretation of genetic information in normal cellular processes and in diseases.
Pediatrics and Cell & Developmental Barbara Davis Center for Diabetes
University of Colorado Anschutz Medical Campus, USA
Dr. Sussel’s research program focuses on the regulation of pancreatic islet cell development, identity and function, which has contributed to the understanding of the islet dysfunction during diabetes. Most recently, she has made significant contributions to the new field of long non-coding RNAs in islet biology.
Marcelo A. Mori
Laboratório de Biologia do Envelhecimento, Institute of Biology
University of Campinas, Brazil
My research interests: I study how the adipose tissue coordinates whole-body metabolism in response to changes in energy availability and how miRNAs play a role in this process.
Laboratory of Obesity and Metabolic Diseases, NIH, Maryland, USA
Molecular and pathologic mechanism of obesity and obesity-induced disorders
Functional analysis of lncRNAs that regulate energy metabolism
Bioinformatics approaches to define lncRNAs associated with cardiometabolic traits
School of Exercise and Nutrition Sciences, Melbourne Burwood Campus, Australia
Dr Severine Lamon’s research focuses on the regulation of skeletal muscle mass and function. Over the last few years, Dr Lamon has been studying the role of microRNAs in muscle adaptation to exercise and disease conditions using cell, rodent and human models. Lately, Dr Lamon and her group have started to investigate the sub-cellular compartmentalization of non-coding RNAs, including microRNAs and long non-coding RNAs
Department of Biomedical Sciences
Cornell University College of Veterinary Medicine, New York, USA
The Sethupathy lab studies the roles of non-coding RNAs in diabetes & metabolic disease, inflammatory bowel disorders, and liver & gastrointestinal cancers. The lab adopts an interdisciplinary research paradigm, leveraging tools and techniques from genetics/genomics, molecular & cell biology, and physiology. The ongoing projects in the lab are funded by the US National Institutes of Health, the Fibrolamellar Cancer Foundation, and the American Diabetes Association Pathway To Stop Diabetes Program
Brigham and Women’s Hospital/Harvard Medical School
Division of Cardiovascular Medicine
Boston, Massachusetts, USA
Dr. Feinberg directs an NIH-funded basic science laboratory that investigates mechanisms leading to the development of atherosclerosis and myocardial infarction. These studies have revealed novel and unexpected pathophysiological roles for non-coding RNAs (microRNAs and lincRNAs) and transcriptional regulators in vascular inflammation and repair, with therapeutic implications for ischemic cardiovascular disease and other acute and chronic inflammatory diseases such as obesity, diabetes, wound healing, and sepsis. He has translated this work from animals to humans and established non-coding RNAs as key pharmacologic targets for therapeutic gain.
Cardiac repair and regeneration requires a well controlled interaction of interstitial cells, such as endothelial cells and fibroblasts, immune cells and cardiomyocytes. Non-coding RNAs, particularly microRNAs, are well known to exhibit various activities in the heart after injury and contribute to the control of repair and regeneration. Particularly long non-coding RNAs exhibit various functions and control epigenetic processes. This lecture will summarize novel approaches targeting non-coding RNAs as therapeutic option to promote cardiac repair and regeneration.
Unit for Endocrinology and Diabetes, Karolinska Institute, Stockholm, Sweden
For 50 years I have worked with the regulation and pathophysiological role of human adipose tissue. This has included metabolic, endocrine and genetic studies. At present my work is concentrated on the non-hormonal regulation. We have extensively studied the role of microRNAs for adipose inflammation. Recently we mapped the transcription factors regulating human fat cell lipolysis. The current work focus on identifying novel long noncoding RNAs of importance for human fat cell differentiation and endocrine/metabolic function. We are elucidating the molecular mechanism of action of these regulators.
My group uses proteomics in combination with other -omics technologies, such as lipidomics and microRNA profiling, to integrate biological information in disease-specific networks that drive pathophysiological changes. While studying molecular interactions has been a research focus for many years and has provided important insight into biology, the attention has now shifted towards a more integrative network biology approach. An example is our first systematic study on circulating microRNAs in cardiometabolic diseases to identify characteristic signatures for platelet activation and risk of metabolic syndrome.
Lempradl Laboratory, Van Andel Research Institute, Michigan, USA
How does parental diet impact the health of future offspring? With mounting evidence that nutrition and metabolism can have a ripple effect through the generations, it is critically important to gain a better understanding of how these processes work in order to develop interventions that improve human health. By determining the molecular mechanisms that underlie phenotype transmission across generations, the Lempradl Laboratory aims to identify and systematically map the nutritional and chemical sources of adverse intergenerational effects. Their ultimate goal is to develop novel ways to prevent transmission of harmful phenotypes to subsequent generations and thus, in the long term, improving health
Lund University Diabetes Centre,
Department of Clinical Sciences,
Lund University, Lund, Sweden
Lena Eliasson is appointed Professor in Experimental Diabetes Research at Lund University and she is part of Lund University Diabetes Centre (LUDC). Her research aims to understand cellular mechanisms underlying impaired islet hormone secretion contributing to the pathogenesis of diabetes. The focus is on single cell physiology involving studies of ion-channels, exocytosis and miRNA networks important in the regulation of islet cell secretion.
Ulf A. Ørom
Institute of Molecular Biology and Genetics, Århus University, Denmark
In my laboratory we use sequencing-based methods to study RNA biogenesis and processing. We have developed the state-of-the-art method for studying primary miRNA processing, revealing important factors that regulate miRNA biogenesis. We have established a targeted approach to study high-depth processing of primary miRNAs from clinical samples and apply this to identify differential primary miRNA processing in the liver.
Institute of Molecular and Cell, BiologyDUKE-NUS Medical School, Singapore.
Modern sedentary lifestyle and consumption of calorie-dense food are precipitating a rapid growing population of metabolic diseases such as obesity, type 2 diabetes and heart diseases. It is predicted, for the first time, that the current generation will have a shorter life-span than previous one. Understanding the molecular mechanisms underlying these metabolic diseases is urgently needed for us to prevent them or develop novel therapeutic strategies. Our studies are revealing a sophisticated RNA-regulatory network governing the development and function of major metabolic organs such as adipose and liver at various physiological and pathological conditions. We aim to determine the role of RNA regulatory network and how these RNA components crosstalk with the more well-understood protein network in the context of metabolic diseases. Our research topics encompass the regulation and function of non-coding RNAs such as microRNAs and lncRNAs, RNA processing such as splicing and editing, and RNA binding proteins.
Integrative Metabolism and Environmental Influences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark
As an academic research scientist, I have developed a world-renowned reputation in the field of metabolic disease, specifically metabolic epigenetics. Throughout my career, I have strived to understand the molecular mechanisms by which environmental factors influence the risk to develop metabolic diseases. My early doctoral work focused on the insulin signalling pathway and allowed identification of potential drug targets for the treatment of type 2 diabetes and insulin-resistance. I established my research niche in metabolic epigenetics and contributed to a seminal study showing that preconceptional exposure to nutritional insult in males predisposes the next generation to metabolic disease. My research team discovered that environmental factors remodel the epigenetic signature of spermatozoa in humans.
NHMRC Clinical Trials Centre, The University of SydneyThe University of Sydney School of Medicine, Australia
Our research is focused on understanding islet cell biology, specifically related to development, differentiation and death of human pancreatic beta cells. We work with cadaveric human pancreatic islets as well as biliary duct and gallbladder-derived cells to gather information that would help us understand development of insulin-producing cells. Our previous studies using next generation sequencing of developing human pancreas have provided insight to understanding the role of ncRNAs in development and differentiation of insulin-producing cells. Present research projects involve applying this information to differentiation of human pancreatic progenitor cells. In addition to these studies, other projects in the lab are focused on understanding the epigenetic modifications in insulin-producing cells in a unique model of multigeneration undernutrition. These studies involve understanding the influence of diet, micronutrients, intrautetine programming and gut microbiota in development of central adiposity, insulin resistance and type 2 diabetes
Exosome Biology Laboratory , Centre for Clinical Diagnostics, UQ Centre for Clinical Research, The University of Queensland, Australia
I am a group leader and senior Lions Medical Research Foundation Fellow working at the University of Queensland Centre for Clinical Research. I am recognized as a national and international researcher working in the field of extracellular vesicles focusing on the reproductive biology (specifically in pregnancy and its complications) and I have been consistently invited as a speaker to both National and International meetings. Within UQCCR, I have established and lead the EXOSOME BIOLOGY LABOARTORY that conforms the ISO standards, in which human exosomes can be isolated, characterised and their role elucidated to evaluate their clinical utility as biomarkers of disease and therapeutic interventions. Over the last 5 years, I have obtained exciting data suggesting that exosomes play a role throughout gestation, including, mediating a placental response to hyperglycaemia and insulin sensitivity.
Director of the Institute of Cardiovascular
Regeneration, Center for Molecular Medicine, University Frankfurt,
School of Cardiovascular Medicine & Science, King's College London, United Kingdom